Austin and San Francisco are about 1,500 miles apart by road. Split the difference and you arrive near Phoenix, the city closest to the halfway point between them. That puts roughly 18 hr 13 min of driving on the Austin side and 13 hr 41 min on the San Francisco side — the fairest single meeting point among the cities near the middle.
Over this distance most people will fly rather than drive the whole way. Phoenix still makes a fair, central place for Austin and San Francisco to converge, splitting the travel instead of asking one side to cross the country.
If Phoenix doesn't have what you're after, Tucson and Albuquerque are also close to the midpoint and worth a look — each keeps the drive reasonably balanced between Austin and San Francisco.
City descriptions adapted from Wikipedia (CC BY-SA); photos via Wikimedia Commons, credited above.