The fair place to meet is Oklahoma City, OK — the city closest to the midpoint of Columbus and Las Vegas. From the farther side that’s about 20 hr 42 min of driving.
Recommended midpoint
Oklahoma City, OK
From Columbus
17 hr 50 min
851 mi to Oklahoma City
From Las Vegas
20 hr 42 min
987 mi to Oklahoma City
Columbus has the shorter trip; the split is off by about 2 hr 52 min. The alternatives below can even it out. Columbus and Las Vegas are about 1,758 miles apart.
Columbus and Las Vegas are about 1,758 miles apart by road. Split the difference and you arrive near Oklahoma City, the city closest to the halfway point between them. That puts roughly 17 hr 50 min of driving on the Columbus side and 20 hr 42 min on the Las Vegas side — the fairest single meeting point among the cities near the middle.
Over this distance most people will fly rather than drive the whole way. Oklahoma City still makes a fair, central place for Columbus and Las Vegas to converge, splitting the travel instead of asking one side to cross the country.
If Oklahoma City doesn't have what you're after, Kansas City and Omaha are also close to the midpoint and worth a look — each keeps the drive reasonably balanced between Columbus and Las Vegas.
Oklahoma City, often shortened to OKC, is the capital and most populous city in the U.S. state of Oklahoma. It is the 21st-most populous U.S. city and 8th largest in the Southern United States, with a population of 681,054 at the 2020 census. Read more →
Columbus is the capital and most populous city of the U.S. state of Ohio. With a population of 905,748 at the 2020 census, it is the 14th-most populous city in the U.S., second-most populous city in the Midwest, and third-most populous U.S. state capital. Read more →
Las Vegas, colloquially shortened to Vegas, is the most populous city in the U.S. state of Nevada and the county seat of Clark County. It is the 24th-most populous city in the United States, with 641,903 residents at the 2020 census. Read more →
City descriptions adapted from Wikipedia (CC BY-SA); photos via Wikimedia Commons, credited above.
Estimates use straight-line distance and typical road speeds; real drive times vary with route and traffic.