The fair place to meet is Dallas-Fort Worth, TX — the city closest to the midpoint of Denver and Tampa. From the farther side that’s about 19 hr 13 min of driving.
Recommended midpoint
Dallas-Fort Worth, TX
From Denver
13 hr 54 min
663 mi to Dallas
From Tampa
19 hr 13 min
917 mi to Dallas
Denver has the shorter trip; the split is off by about 5 hr 19 min. The alternatives below can even it out. Denver and Tampa are about 1,521 miles apart.
Denver and Tampa are about 1,521 miles apart by road. Split the difference and you arrive near Dallas, the city closest to the halfway point between them. That puts roughly 13 hr 54 min of driving on the Denver side and 19 hr 13 min on the Tampa side — the fairest single meeting point among the cities near the middle.
Over this distance most people will fly rather than drive the whole way. Dallas still makes a fair, central place for Denver and Tampa to converge, splitting the travel instead of asking one side to cross the country.
If Dallas doesn't have what you're after, Memphis and Oklahoma City are also close to the midpoint and worth a look — each keeps the drive reasonably balanced between Denver and Tampa.
Dallas is a city in the U.S. state of Texas. Located in the state's northern region, it is the ninth-most populous city in the United States and third-most populous city in Texas, with a population of 1.3 million at the 2020 census. Read more →
Denver is the capital and most populous city of the U.S. state of Colorado. Officially a consolidated city and county, it is located in the South Platte River valley on the western edge of the High Plains, and is just east of the Front Range of the Rocky… Read more →
Tampa is a major city on the Gulf Coast of the U.S. state of Florida and the county seat of Hillsborough County. Tampa's borders include the north shore of Tampa Bay and the east shore of Old Tampa Bay. Read more →
City descriptions adapted from Wikipedia (CC BY-SA); photos via Wikimedia Commons, credited above.
Estimates use straight-line distance and typical road speeds; real drive times vary with route and traffic.