The fair place to meet is Dallas-Fort Worth, TX — the city closest to the midpoint of Las Vegas and Orlando. From the farther side that’s about 22 hr 25 min of driving.
Recommended midpoint
Dallas-Fort Worth, TX
From Las Vegas
22 hr 25 min
1,069 mi to Dallas
From Orlando
20 hr 9 min
961 mi to Dallas
Orlando has the shorter trip; the split is off by about 2 hr 16 min. The alternatives below can even it out. Las Vegas and Orlando are about 2,029 miles apart.
Las Vegas and Orlando are about 2,029 miles apart by road. Split the difference and you arrive near Dallas, the city closest to the halfway point between them. That puts roughly 22 hr 25 min of driving on the Las Vegas side and 20 hr 9 min on the Orlando side — the fairest single meeting point among the cities near the middle.
Over this distance most people will fly rather than drive the whole way. Dallas still makes a fair, central place for Las Vegas and Orlando to converge, splitting the travel instead of asking one side to cross the country.
If Dallas doesn't have what you're after, Austin and San Antonio are also close to the midpoint and worth a look — each keeps the drive reasonably balanced between Las Vegas and Orlando.
Dallas is a city in the U.S. state of Texas. Located in the state's northern region, it is the ninth-most populous city in the United States and third-most populous city in Texas, with a population of 1.3 million at the 2020 census. Read more →
Las Vegas, colloquially shortened to Vegas, is the most populous city in the U.S. state of Nevada and the county seat of Clark County. It is the 24th-most populous city in the United States, with 641,903 residents at the 2020 census. Read more →
Orlando is a city in and the county seat of Orange County, Florida, United States. Part of Central Florida, it is the fourth-most populous city in the state and its most populous inland city, with a population of 307,573 at the 2020 census. Read more →
City descriptions adapted from Wikipedia (CC BY-SA); photos via Wikimedia Commons, credited above.
Estimates use straight-line distance and typical road speeds; real drive times vary with route and traffic.