The fair place to meet is Kansas City, MO — the city closest to the midpoint of Minneapolis and San Antonio. From the farther side that’s about 14 hr 47 min of driving.
Recommended midpoint
Kansas City, MO
From Minneapolis
8 hr 38 min
412 mi to Kansas City
From San Antonio
14 hr 47 min
705 mi to Kansas City
Minneapolis has the shorter trip; the split is off by about 6 hr 9 min. The alternatives below can even it out. Minneapolis and San Antonio are about 1,112 miles apart.
Minneapolis and San Antonio are about 1,112 miles apart by road. Split the difference and you arrive near Kansas City, the city closest to the halfway point between them. That puts roughly 8 hr 38 min of driving on the Minneapolis side and 14 hr 47 min on the San Antonio side — the fairest single meeting point among the cities near the middle.
Over this distance most people will fly rather than drive the whole way. Kansas City still makes a fair, central place for Minneapolis and San Antonio to converge, splitting the travel instead of asking one side to cross the country.
If Kansas City doesn't have what you're after, Oklahoma City and Omaha are also close to the midpoint and worth a look — each keeps the drive reasonably balanced between Minneapolis and San Antonio.
Kansas City, abbreviated KC or KCMO, is the largest city in the U.S. state of Missouri by both population and area. It is located on the Missouri River at its confluence with the Kansas River, within Jackson, Clay, Platte and Cass counties. Read more →
Minneapolis is a city in Hennepin County, Minnesota, United States, and its county seat. With a population of 429,954 as of the 2020 census, it is the state's most populous city. Read more →
San Antonio is a city in the U.S. state of Texas. It is the seventh-most populous city in the United States, the second-most populous city in Texas, and the second-most populous city in the Southern U.S., with a population of 1.43 million at the 2020 census. Read more →
City descriptions adapted from Wikipedia (CC BY-SA); photos via Wikimedia Commons, credited above.
Estimates use straight-line distance and typical road speeds; real drive times vary with route and traffic.