The fair place to meet is Albuquerque, NM — the city closest to the midpoint of Omaha and San Diego. From the farther side that’s about 15 hr 7 min of driving.
Recommended midpoint
Albuquerque, NM
From Omaha
15 hr 7 min
721 mi to Albuquerque
From San Diego
13 hr 5 min
624 mi to Albuquerque
San Diego has the shorter trip; the split is off by about 2 hr 2 min. The alternatives below can even it out. Omaha and San Diego are about 1,307 miles apart.
Omaha and San Diego are about 1,307 miles apart by road. Split the difference and you arrive near Albuquerque, the city closest to the halfway point between them. That puts roughly 15 hr 7 min of driving on the Omaha side and 13 hr 5 min on the San Diego side — the fairest single meeting point among the cities near the middle.
Over this distance most people will fly rather than drive the whole way. Albuquerque still makes a fair, central place for Omaha and San Diego to converge, splitting the travel instead of asking one side to cross the country.
If Albuquerque doesn't have what you're after, Denver and El Paso are also close to the midpoint and worth a look — each keeps the drive reasonably balanced between Omaha and San Diego.
Albuquerque is the most populous city in the U.S. state of New Mexico. Founded in 1706 as La Villa de Alburquerque by Santa Fe de Nuevo México governor Francisco Cuervo y Valdés, and named in honor of Francisco Fernández de la Cueva, 10th Duke of Alburquerque… Read more →
Omaha is the most populous city in the U.S. state of Nebraska. It is located in the Midwestern United States along the Missouri River, about 10 mi (15 km) north of the mouth of the Platte River. Read more →
San Diego is a city on the Pacific coast of Southern California, adjacent to the Mexico–United States border. It is the eighth-most populous city in the U.S. Read more →
City descriptions adapted from Wikipedia (CC BY-SA); photos via Wikimedia Commons, credited above.
Estimates use straight-line distance and typical road speeds; real drive times vary with route and traffic.