The fair place to meet is Oklahoma City, OK — the city closest to the midpoint of Orlando and Sacramento. From the farther side that’s about 28 hr 1 min of driving.
Recommended midpoint
Oklahoma City, OK
From Orlando
22 hr 11 min
1,058 mi to Oklahoma City
From Sacramento
28 hr 1 min
1,336 mi to Oklahoma City
Orlando has the shorter trip; the split is off by about 5 hr 50 min. The alternatives below can even it out. Orlando and Sacramento are about 2,391 miles apart.
Orlando and Sacramento are about 2,391 miles apart by road. Split the difference and you arrive near Oklahoma City, the city closest to the halfway point between them. That puts roughly 22 hr 11 min of driving on the Orlando side and 28 hr 1 min on the Sacramento side — the fairest single meeting point among the cities near the middle.
Over this distance most people will fly rather than drive the whole way. Oklahoma City still makes a fair, central place for Orlando and Sacramento to converge, splitting the travel instead of asking one side to cross the country.
If Oklahoma City doesn't have what you're after, Dallas and Austin are also close to the midpoint and worth a look — each keeps the drive reasonably balanced between Orlando and Sacramento.
Oklahoma City, often shortened to OKC, is the capital and most populous city in the U.S. state of Oklahoma. It is the 21st-most populous U.S. city and 8th largest in the Southern United States, with a population of 681,054 at the 2020 census. Read more →
Orlando is a city in and the county seat of Orange County, Florida, United States. Part of Central Florida, it is the fourth-most populous city in the state and its most populous inland city, with a population of 307,573 at the 2020 census. Read more →
Sacramento is the capital city of the U.S. state of California. The county seat of Sacramento County, it is located at the confluence of the Sacramento and American Rivers in the Sacramento Valley. Read more →
City descriptions adapted from Wikipedia (CC BY-SA); photos via Wikimedia Commons, credited above.
Estimates use straight-line distance and typical road speeds; real drive times vary with route and traffic.