Salt Lake City and Tampa are about 1,885 miles apart by road. Split the difference and you arrive near Oklahoma City, the city closest to the halfway point between them. That puts roughly 18 hr 4 min of driving on the Salt Lake City side and 21 hr 29 min on the Tampa side — the fairest single meeting point among the cities near the middle.
Over this distance most people will fly rather than drive the whole way. Oklahoma City still makes a fair, central place for Salt Lake City and Tampa to converge, splitting the travel instead of asking one side to cross the country.
If Oklahoma City doesn't have what you're after, Dallas and Austin are also close to the midpoint and worth a look — each keeps the drive reasonably balanced between Salt Lake City and Tampa.
City descriptions adapted from Wikipedia (CC BY-SA); photos via Wikimedia Commons, credited above.