The fair place to meet is Charlotte, NC — the city closest to the midpoint of Boston and Houston. From the farther side that’s about 19 hr 25 min of driving.
Recommended midpoint
Charlotte, NC
From Boston
15 hr 7 min
721 mi to Charlotte
From Houston
19 hr 25 min
926 mi to Charlotte
Boston has the shorter trip; the split is off by about 4 hr 18 min. The alternatives below can even it out. Boston and Houston are about 1,604 miles apart.
Boston and Houston are about 1,604 miles apart by road. Split the difference and you arrive near Charlotte, the city closest to the halfway point between them. That puts roughly 15 hr 7 min of driving on the Boston side and 19 hr 25 min on the Houston side — the fairest single meeting point among the cities near the middle.
Over this distance most people will fly rather than drive the whole way. Charlotte still makes a fair, central place for Boston and Houston to converge, splitting the travel instead of asking one side to cross the country.
If Charlotte doesn't have what you're after, Atlanta and Nashville are also close to the midpoint and worth a look — each keeps the drive reasonably balanced between Boston and Houston.
Charlotte is the most populous city in the U.S. state of North Carolina. With a population of 874,579 at the 2020 census, it is the 14th-most populous city in the U.S., seventh-most populous city in the South, and second-most populous city in the Southeast. Read more →
Boston is the capital and most populous city of the U.S. state of Massachusetts. It serves as a cultural and financial center of New England, a region of the Northeastern United States. Read more →
Houston is the most populous city in the U.S. state of Texas and the Southern United States. It is the fourth-most populous city in the United States, with a population of 2.3 million at the 2020 census. Read more →
City descriptions adapted from Wikipedia (CC BY-SA); photos via Wikimedia Commons, credited above.
Estimates use straight-line distance and typical road speeds; real drive times vary with route and traffic.