The fair place to meet is Detroit, MI — the city closest to the midpoint of Boston and Minneapolis. From the farther side that’s about 12 hr 49 min of driving.
Recommended midpoint
Detroit, MI
From Boston
12 hr 49 min
612 mi to Detroit
From Minneapolis
11 hr 22 min
542 mi to Detroit
Minneapolis has the shorter trip; the split is off by about 1 hr 27 min. The alternatives below can even it out. Boston and Minneapolis are about 1,121 miles apart.
Boston and Minneapolis are about 1,121 miles apart by road. Split the difference and you arrive near Detroit, the city closest to the halfway point between them. That puts roughly 12 hr 49 min of driving on the Boston side and 11 hr 22 min on the Minneapolis side — the fairest single meeting point among the cities near the middle.
Over this distance most people will fly rather than drive the whole way. Detroit still makes a fair, central place for Boston and Minneapolis to converge, splitting the travel instead of asking one side to cross the country.
If Detroit doesn't have what you're after, Cleveland and Buffalo are also close to the midpoint and worth a look — each keeps the drive reasonably balanced between Boston and Minneapolis.
Detroit is the most populous city in the U.S. state of Michigan. It is situated on the bank of the Detroit River across from the Canadian city of Windsor, Ontario. It is the 26th-most populous city in the United States and the largest U.S. Read more →
Boston is the capital and most populous city of the U.S. state of Massachusetts. It serves as a cultural and financial center of New England, a region of the Northeastern United States. Read more →
Minneapolis is a city in Hennepin County, Minnesota, United States, and its county seat. With a population of 429,954 as of the 2020 census, it is the state's most populous city. Read more →
City descriptions adapted from Wikipedia (CC BY-SA); photos via Wikimedia Commons, credited above.
Estimates use straight-line distance and typical road speeds; real drive times vary with route and traffic.