The fair place to meet is Indianapolis, IN — the city closest to the midpoint of Charlotte and Minneapolis. From the farther side that’s about 10 hr 42 min of driving.
Recommended midpoint
Indianapolis, IN
From Charlotte
8 hr 58 min
428 mi to Indianapolis
From Minneapolis
10 hr 42 min
511 mi to Indianapolis
Charlotte has the shorter trip; the split is off by about 1 hr 44 min. The alternatives below can even it out. Charlotte and Minneapolis are about 939 miles apart.
Charlotte and Minneapolis are about 939 miles apart by road. Split the difference and you arrive near Indianapolis, the city closest to the halfway point between them. That puts roughly 8 hr 58 min of driving on the Charlotte side and 10 hr 42 min on the Minneapolis side — the fairest single meeting point among the cities near the middle.
Over this distance most people will fly rather than drive the whole way. Indianapolis still makes a fair, central place for Charlotte and Minneapolis to converge, splitting the travel instead of asking one side to cross the country.
If Indianapolis doesn't have what you're after, Chicago and Louisville are also close to the midpoint and worth a look — each keeps the drive reasonably balanced between Charlotte and Minneapolis.
Indianapolis, colloquially known as Indy, is the capital and most populous city of the U.S. state of Indiana and the county seat of Marion County. Indianapolis is situated in the state's central till plain region along the west fork of the White River. Read more →
Charlotte is the most populous city in the U.S. state of North Carolina. With a population of 874,579 at the 2020 census, it is the 14th-most populous city in the U.S., seventh-most populous city in the South, and second-most populous city in the Southeast. Read more →
Minneapolis is a city in Hennepin County, Minnesota, United States, and its county seat. With a population of 429,954 as of the 2020 census, it is the state's most populous city. Read more →
City descriptions adapted from Wikipedia (CC BY-SA); photos via Wikimedia Commons, credited above.
Estimates use straight-line distance and typical road speeds; real drive times vary with route and traffic.