The fair place to meet is Richmond, VA — the city closest to the midpoint of Charlotte and Pittsburgh. From the farther side that’s about 5 hr 12 min of driving.
Recommended midpoint
Richmond, VA
From Charlotte
5 hr 12 min
248 mi to Richmond
From Pittsburgh
5 hr 6 min
243 mi to Richmond
That’s an even split — both sides drive within 6 min of each other. Charlotte and Pittsburgh are about 363 miles apart.
Charlotte and Pittsburgh are about 363 miles apart by road. Split the difference and you arrive near Richmond, the city closest to the halfway point between them. That splits the trip almost evenly — about 5 hr 12 min from Charlotte and 5 hr 6 min from Pittsburgh.
That's a half-day drive from each side, so Richmond suits an overnight or a weekend rather than a quick coffee — long enough to want a reason to stay, short enough to drive.
If Richmond doesn't have what you're after, Raleigh and Washington are also close to the midpoint and worth a look — each keeps the drive reasonably balanced between Charlotte and Pittsburgh.
Richmond is the capital city of the U.S. state of Virginia. Incorporated in 1742, Richmond has been an independent city since 1871. It is the fourth-most populous city in Virginia, with a population of 226,610 at the 2020 census. Read more →
Charlotte is the most populous city in the U.S. state of North Carolina. With a population of 874,579 at the 2020 census, it is the 14th-most populous city in the U.S., seventh-most populous city in the South, and second-most populous city in the Southeast. Read more →
Pittsburgh is a city in Allegheny County, Pennsylvania, United States, and its county seat. Read more →
City descriptions adapted from Wikipedia (CC BY-SA); photos via Wikimedia Commons, credited above.
Estimates use straight-line distance and typical road speeds; real drive times vary with route and traffic.