The fair place to meet is Albuquerque, NM — the city closest to the midpoint of Houston and Portland. From the farther side that’s about 23 hr 12 min of driving.
Recommended midpoint
Albuquerque, NM
From Houston
15 hr 47 min
753 mi to Albuquerque
From Portland
23 hr 12 min
1,107 mi to Albuquerque
Houston has the shorter trip; the split is off by about 7 hr 25 min. The alternatives below can even it out. Houston and Portland are about 1,834 miles apart.
Houston and Portland are about 1,834 miles apart by road. Split the difference and you arrive near Albuquerque, the city closest to the halfway point between them. That puts roughly 15 hr 47 min of driving on the Houston side and 23 hr 12 min on the Portland side — the fairest single meeting point among the cities near the middle.
Over this distance most people will fly rather than drive the whole way. Albuquerque still makes a fair, central place for Houston and Portland to converge, splitting the travel instead of asking one side to cross the country.
If Albuquerque doesn't have what you're after, Denver and Salt Lake City are also close to the midpoint and worth a look — each keeps the drive reasonably balanced between Houston and Portland.
Albuquerque is the most populous city in the U.S. state of New Mexico. Founded in 1706 as La Villa de Alburquerque by Santa Fe de Nuevo México governor Francisco Cuervo y Valdés, and named in honor of Francisco Fernández de la Cueva, 10th Duke of Alburquerque… Read more →
Houston is the most populous city in the U.S. state of Texas and the Southern United States. It is the fourth-most populous city in the United States, with a population of 2.3 million at the 2020 census. Read more →
Portland is the most populous city in the U.S. state of Oregon. Located in the Pacific Northwest at the confluence of the Willamette and Columbia rivers, it is the 28th-most populous city in the United States, sixth-most populous on the West Coast, and… Read more →
City descriptions adapted from Wikipedia (CC BY-SA); photos via Wikimedia Commons, credited above.
Estimates use straight-line distance and typical road speeds; real drive times vary with route and traffic.