The fair place to meet is Charlotte, NC — the city closest to the midpoint of Buffalo and Miami. From the farther side that’s about 13 hr 44 min of driving.
Recommended midpoint
Charlotte, NC
From Buffalo
11 hr 19 min
540 mi to Charlotte
From Miami
13 hr 44 min
655 mi to Charlotte
Buffalo has the shorter trip; the split is off by about 2 hr 25 min. The alternatives below can even it out. Buffalo and Miami are about 1,186 miles apart.
Buffalo and Miami are about 1,186 miles apart by road. Split the difference and you arrive near Charlotte, the city closest to the halfway point between them. That puts roughly 11 hr 19 min of driving on the Buffalo side and 13 hr 44 min on the Miami side — the fairest single meeting point among the cities near the middle.
Over this distance most people will fly rather than drive the whole way. Charlotte still makes a fair, central place for Buffalo and Miami to converge, splitting the travel instead of asking one side to cross the country.
If Charlotte doesn't have what you're after, Raleigh and Richmond are also close to the midpoint and worth a look — each keeps the drive reasonably balanced between Buffalo and Miami.
Charlotte is the most populous city in the U.S. state of North Carolina. With a population of 874,579 at the 2020 census, it is the 14th-most populous city in the U.S., seventh-most populous city in the South, and second-most populous city in the Southeast. Read more →
Buffalo is a city in the U.S. state of New York. It lies in Western New York on the eastern shore of Lake Erie and at the head of the Niagara River on the Canada–United States border. Read more →
Miami is a coastal city in the U.S. state of Florida. It is the second-most populous city proper in Florida, with a population of 442,241 at the 2020 census. Read more →
City descriptions adapted from Wikipedia (CC BY-SA); photos via Wikimedia Commons, credited above.
Estimates use straight-line distance and typical road speeds; real drive times vary with route and traffic.