Nashville and Tucson are about 1,405 miles apart by road. Split the difference and you arrive near Oklahoma City, the city closest to the halfway point between them. That puts roughly 12 hr 39 min of driving on the Nashville side and 16 hr 51 min on the Tucson side — the fairest single meeting point among the cities near the middle.
Over this distance most people will fly rather than drive the whole way. Oklahoma City still makes a fair, central place for Nashville and Tucson to converge, splitting the travel instead of asking one side to cross the country.
If Oklahoma City doesn't have what you're after, Dallas and Austin are also close to the midpoint and worth a look — each keeps the drive reasonably balanced between Nashville and Tucson.
City descriptions adapted from Wikipedia (CC BY-SA); photos via Wikimedia Commons, credited above.